Extinction of sequential conditioned inhibition

Temporally Specific Extinction of Pavlovian Conditioned Inhibition

Extinction Generates Outcome-Specific Conditioned Inhibition

Extinction involves altering a previously established predictive relationship between a cue and its outcome by repeatedly presenting that cue alone. Although it is widely accepted that extinction generates some form of inhibitory learning [1-4], direct evidence for this claim has been lacking, and the nature of the associative changes induced by extinction have, therefore, remained a matter of ...

Extinction of conditioned inhibition: effects of different outcome continua.

For some decades, failures to find extinction of inhibition through unpaired presentations of the inhibitor were taken as evidence against conceptualizing inhibition as the symmetrical counterpart of excitation. Recently, however, our group has demonstrated successful extinction of inhibition in human causal learning. In two experiments, we replicated and strengthened this finding by using an o...

Reconsolidation and extinction of conditioned fear: inhibition and potentiation.

NMDA receptors are important for the acquisition, reconsolidation, and extinction of memories. NMDA receptor antagonists impair these memory processes, whereas the partial agonist D-cycloserine (DCS) potentiates both learning and extinction. Here, we used DCS and the noncompetitive NMDA receptor antagonist (+)-5-methyl-10,11-dihydro-SH-dibenzo[a,d]cyclohepten-5,10-imine maleate (MK-801) to inve...

Inhibition of Cav2.2-mediated signaling disrupts conditioned fear extinction

Neuronal voltage gated calcium channels (VGCCs) are well known for its importance in synaptic transmission and signaling pathway in the specific circuits. On the other hand, the role of different VGCCs in the cognitive functions has not been studied. Although it has been reported that fear extinction requires Cav2.1-regulated N-methyl-D-aspartate (NMDA) receptor signaling, Cav2.2-regulated syna...